A new classification of liver cancer

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The research at Children’s Hospital Los Angeles has undergone and lead to the rise of new liver tumor hepatocellular malignant neoplasm-NOS (HEMNOS). It has two characteristics of the pediatric liver cancer hepatoblastoma (HB), hepatocellular carcinoma (HCC) seen in adults.

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HEMNOS had been said to have a very poor course of medication. The research organized and studied the cases of 11 patients with liver cancer age group of 4 to 15 from 2000-2016.

The patients received HB-targeted chemotherapy and complete surgical resection. However, all the patients survived and achieved considered high risk.

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The doctors performed analyses to define unique group of tumors. The review of pre-chemotherapy revealed six tumors. Overlapping tissue features had predominant HB histology, along with HCC-like histology and HB histology.

Investigators also examined the expression of the telomerase gene (TERT), a protein in DNA complex crucial for the survival of cancer cells. Also found TERT expression in nine of the 11 cases.

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In addition the researchers organize a study to know the genomic difference of the HEMNOS tumor. And differentiate both classic hepatoblastoma and hepatocellularcarcinoma to get into the pathophysiology of this cancer.

 

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